Creatine Monohydrate: Evidence-Based Supplementation for Physical Performance and Cognitive Function
Creatine monohydrate stands as the most extensively researched and empirically validated ergogenic compound in sports nutrition. Beyond its established efficacy in augmenting strength, anaerobic power, and lean muscle mass, cutting-edge neurobiology highlights its vital function in cerebral bioenergetics, cellular neuroprotection, and working memory. This comprehensive review examines intracellular phosphorylation mechanisms, optimal titration protocols, safety profiles, and clinical evidence disproving renal toxicity myths.