Since ancient times, people have been interested in health by studying the impact of plants and food on the health condition and regenerative abilities of the body. In the past, it was believed that fermented milk beverages were beneficial for the digestive system. Over time, the existence of gut flora was discovered, and research on it continues to this day. Our current understanding of the human ecosystem is still relatively small, but we know that the intestinal system itself contains around 100 trillion bacteria belonging to over 100 different species. Most of them are non-edible organisms. Each person has their unique pattern of intestinal bacteria, similar to fingerprints, which is exclusive to them. However, the composition of bacteria is not static and can change under the influence of factors such as diet, pharmacotherapy, antibiotic therapy, drugs, or stress. A destroyed gut flora can, however, be rebuilt by consuming probiotic products or preparations.
Probiotics: Definition, Mechanisms of Action, and Health Benefits for Humans
Probiotics are viable microbial organisms that, when administered in adequate quantities, confer scientifically validated benefits to human health. Ongoing research continues to refine which specific strains meet the stringent criteria for probiotic classification. Currently, the category of microorganisms with confirmed probiotic properties primarily includes lactic acid bacteria—such as *Lactobacillus acidophilus*, *Lactobacillus casei*, *Lactobacillus reuteri*, *Lactobacillus rhamnosus*, *Bifidobacterium animalis*, and *Bifidobacterium breve*—as well as the yeast *Saccharomyces boulardii*. Clinical evidence demonstrates that dietary supplementation with these strains facilitates the maintenance of gastrointestinal homeostasis and enhances the organism’s resilience to exogenous stressors. A well-functioning digestive system ensures optimal nutrient absorption. Notably, probiotics exhibit functional similarities to the native gut microbiota, underpinning their multifaceted health-promoting effects. The principal roles of probiotics encompass: **protective barrier formation** (colonization of intestinal mucosa to inhibit pathogenic adhesion), **digestive enhancement** (augmentation of enzymatic activity), **immunomodulatory action** (stimulation of the body’s defensive mechanisms), and **anticarcinogenic potential** (detoxification of mutagenic compounds).
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