Vitamin B8 (Inositol) – Functions and Effects of Deficiency

Inocytol is an organic compound that belongs to the sugar group and has a sweet taste. Although some sources attribute inocytol to the function of a vitamin, (and classify it as vitamin B8), this statement is not entirely correct. The human body is able to synthesize this compound in limited quantities, which contradicts the definition of vitamin. The first mention of 'vitamin B8' dates back to 1848, but its important role in metabolism was only described in 1941. Today, it is known that endogenous synthesis of inocytol occurs mainly in the brain, liver, and kidneys, from where it is transported to other organs through the bloodstream. The other organs are supplied with inocytol through arteries. This compound can also be provided to the body through food, and its main sources are, for example, raisins, grapefruits, peanuts, beans, liver, wheat germ, and whole-grain cereal products. A well-balanced diet can provide almost 1g of this compound, while the appropriate organ synthesis can provide an additional 2g. This amount is sufficient to meet the daily requirement, but it should be noted that the daily requirement can change, depending on how the day is spent. For example, the organisms of active people require more inocytol.

Long-term research on inositol has not only helped determine its source, but also define a wide range of functions it fulfills in our bodies. It has been established that the compound plays a significant role in the transmission of information between neurons in the nervous system, which impacts mental comfort and health maintenance. Many experts recommend it as one of the best natural remedies that not only decreases the frequency of panic attacks and anxiety states but also has a positive impact on brain cell function. Clinical studies have also proven the therapeutic effects of inositol on the symptoms of bulimia. Due to its broad spectrum of effects, inositol has found use as a component of products intended for weight reduction and supplements supporting this process. There are also scientific evidence of the compound's impact on fat metabolism, which appears to be strengthened by the synergistic activity of choline. The combination of both substances improves the lipid parameters of the blood and facilitates the removal of lipids from the liver, reducing the risk of liver diseases associated with excessive fat. The positive effect of inositol on the function of carbohydrate metabolism has also been proven by many independent clinical studies. A therapy with inositol also brings positive results in patients with polycystic ovary syndrome (PCOS), reducing the number of anovulatory cycles.

The deficiency of pseudo-vitamins in our organism can bring about various outcomes. Among the most frequently described in scientific literature are: effects on skin condition – dryness, spots, rashes; effects on fertility – ovulation disorders, issues related to the spermatogenesis process; impact on the worsening of organ function – fatty liver; effect on the functioning of the nervous system – discomfort, panic attacks, obsessions.

Although there is evidence of the positive impact of biotin on maintaining normal maternal blood glucose levels during pregnancy, there is still insufficient data to confirm the safety of this substance during both pregnancy and breastfeeding. However, it is important to note that this refers to additional supplementation, as biotins provided through a diet in accordance with daily requirements do not pose a threat.

Based on the current level of knowledge, it has been confirmed that low levels of inositol in the body exhibit an interaction with an increased risk of developing a depressive disorder. One of the most common reasons for this is a decrease in serotonin activity in the central nervous system. Since 'vitamin' B8 has an influence on the modulation of the functioning of this neurotransmitter, it is assumed that it may also have significance in alleviating the symptoms of the disease. Among individuals undergoing therapy, an increase in motivation, a decrease in mood fluctuations, a decrease in chronic fatigue, and the disappearance of apathetic states have been noted.