Czy rzeczywiście olej kanabidiolowy z konopi przemysłowych wykazuje właściwości lecznicze i jakie są mechanizmy jego działania?
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Terapia z wykorzystaniem preparatów na bazie konopi wzbudza intensywne dyskusje zarówno w środowisku medycznym, jak i społecznym. Od momentu nowelizacji przepisów prawnych w roku 2017, produkty zawierające kannabinoidy o statusie leków recepturowych są w Polsce dopuszczone do obrotu, jednak ich wydawanie ograniczone jest do ściśle określonej grupy wskazań klinicznych. Pomimo tego, dostępność tych specyfików w sieci aptek pozostaje – zgodnie z aktualnym stanem wiedzy (na dzień sporządzania niniejszego opracowania) – wysoce ograniczona, co praktycznie uniemożliwia ich powszechne stosowanie przez pacjentów.
Cannabidiol? What is it?
Cannabinoids are the active substances in hemp. They interact with the cannabinoid receptors present in mammalian organisms. The cannabinoids with high pharmacological potential are cannabidiol (CBD) and tetrahydrocannabidiol (THC). Marijuana contains both THC and CBD. THC is stronger in action and causes hallucinations.
The composition of CBD oil
Omega-6 and omega-3 fatty acids in a 3:1 ratio of calcium magnesium zinc to vitamin E, A, B, K.
The properties
CBD primarily has pain-relieving and relaxing effects, but it also works: antibacterial anti-inflammatory and reduces neurodegenerative disorders. Antipsychotic, anti-depressant and anti-cancer in the treatment of addictions. In 2013, the U.S. Food and Drug Administration (FDA) and the European Medecins Agency (EMA) in Europe approved the start of studies on cannabinoids to treat epilepsy in children.
The mechanism of action
Studies on the effects of cannabidiol on the human body are most often considered in the context of inhibiting the development of cancers, but according to current knowledge the mechanism of action of CBD has not yet been fully understood. Currently, the most commonly proposed scheme of action for CBD in vitro is to limit the production of reactive forms of oxygen whose excess in the body contributes to cell death (apoptosis). Numerous scientific studies have shown similar mechanisms of action in relation to different lines of cancer cells, e.g. polycystic kidney, breast cells, prostate gland, or leukemia.
How to use hemp oil
The easiest way is to take the oil orally, with a few drops under the tongue several times a day. Add it to food or drinks, it's important to avoid frying or cooking that deprives it of its medicinal properties. Inhalation Liquid CBD oils are becoming popular for use in e-cigarettes. Vaporization is a very effective way of applying CBD to the lungs and bloodstream.
Legality in Poland
In Poland, the possession and use of CBD is legal. It is obtained by the process of pressing cannabis. The available form of cannabidiol is hemp oil containing CBD (e.g. 4%-5%-10%), and at the same time not containing THC. The number of places offering extracts is constantly increasing.
Price, where to buy
The price of 10 milliliters of cannabis oil is high, the good ones cost a lot more than $100. The interest in cannabidiol is growing, but there is also scientific research that allows us to verify reliably whether the substances contained in cannabis have more benefits or harm to human health.